How to Read PGT Report

How to Read PGT Report

Core Answer

Most PGT reports can be understood by focusing on three result groups: euploid, mosaic, and aneuploid embryos. Some reports may also show no result or inconclusive result.

The report is not just a label. It should be discussed with the fertility doctor, embryology team, and when needed, a genetic counselor.

Euploid

Euploid means the tested sample shows the expected number of chromosomes. In many clinics, euploid embryos are prioritized for transfer because they are associated with higher implantation potential and lower miscarriage risk compared with aneuploid embryos.

This still does not guarantee pregnancy. Uterine readiness, transfer timing, embryo biology, and patient factors remain important.

Mosaic

Mosaic means the tested sample contains a mixture of cells interpreted as normal and abnormal. Mosaic results need careful discussion because risk can vary by the chromosomes involved, the estimated mosaic level, and clinic policy.

Not all mosaic embryos are treated the same. Some may be considered for transfer when no euploid embryo is available, but this decision should include counseling about uncertainty, prenatal testing, and follow-up.

Aneuploid

Aneuploid means the tested sample shows abnormal chromosome copy number. These embryos are generally not recommended for transfer because the risk of implantation failure, miscarriage, or abnormal pregnancy is higher.

The report may specify which chromosome is affected and whether the abnormality is whole-chromosome or segmental. Ask your doctor what the result means in plain language.

No Result or Inconclusive

Sometimes the lab cannot produce a clear result. This may happen because of sample quality, amplification failure, or technical limitations. The next step could be re-biopsy, continued storage, or deprioritizing the embryo, depending on clinic policy and embryo condition.

What Else to Read on the Report

Embryo grade still matters, but it is separate from chromosome status. A high-grade embryo is not automatically euploid, and a euploid embryo may not always have the highest visual grade.

Check the embryo ID, biopsy day, result category, embryo grade, and any lab comments. Make sure the embryo selected for transfer matches the report and the clinic’s transfer plan.

Questions to Ask

Ask:

  1. Which embryos are transferable in this clinic?
  2. If there is a mosaic embryo, what is the estimated mosaic level?
  3. Are any chromosomes or segmental findings considered higher risk?
  4. Is genetic counseling recommended before transfer?
  5. What pregnancy screening or prenatal testing will still be needed?

Common Misunderstandings

“High grade” does not mean “will definitely succeed.”

“Mosaic” does not always mean “never usable.”

“Normal PGT” does not remove the need for pregnancy monitoring and prenatal care.

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